2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-176223
    Antimalarial agent 51
    Antimalarial agent 51 (Compound 2) is an orally active antimalarial compound. Antimalarial agent 51 blocks nutrient uptake by Plasmodium by inhibiting the plasmodium surface anion channel (PSAC). Antimalarial agent 51 significantly inhibits the growth of Plasmodium under nutrient-restricted conditions. Combination of antimalarial agent 51 with the residual transport inhibitor PRT-2 can enhance the antimalarial effect. Antimalarial agent 51 can be used in the study of malaria targeting the PSAC channel.
    Antimalarial agent 51
  • HY-N10263
    Palmarumycin C3
    Palmarumycin C3 is a spirobisnaphthalene compound isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. Palmarumycin C3 exhibits stronger antimicrobial and antioxidant activities.
    Palmarumycin C3
  • HY-106866
    Bulaquine
    		Inhibitor
    Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria.
    Bulaquine
  • HY-183262
    Antileishmanial agent-40
    		Inhibitor
    Antileishmanial agent-40 is an orally active and selective antileishmanial agent. Antileishmanial agent-40 elevates intracellular reactive oxygen species (ROS) levels in Leishmania donovani promastigotes. Antileishmanial agent-40 induces cell cycle arrest at the sub-G0/G1 phase in Leishmania donovani promastigotes, indicative of programmed-like parasite death. Antileishmanial agent-40 can be used for the research of leishmaniasis.
    Antileishmanial agent-40
  • HY-12987S2
    Pimozide-d4-1
    		Inhibitor
    Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
    Pimozide-d<sub>4</sub>-1
  • HY-128399
    CpCDPK1/TgCDPK1-IN-3
    		Inhibitor
    CpCDPK1/TgCDPK1-IN-3 (Compound 20) is a CpCDPK1 and TgCDPK1 inhibitor with IC50 values of 0.003 and 0.0036 µM, respectively. CpCDPK1/TgCDPK1-IN-3 can be used in the research of apicomplexan protozoa-related diseases, such as the research of T. gondii, C. parvum and C. hominus infection.
    CpCDPK1/TgCDPK1-IN-3
  • HY-155400
    Antitrypanosomal agent 17
    		Inhibitor
    Antitrypanosomal agent 17 (Compd 7a) possesses antiamastigote activity, with an IC50 of 0.03 μM against T. congolense strain IL3000.
    Antitrypanosomal agent 17
  • HY-115905
    Antimalarial agent 9
    		Inhibitor
    Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC50-0.14 μM) and MDR strain (IC50-0.41 μM) with minimal cytotoxicity and high selectivity.
    Antimalarial agent 9
  • HY-150066
    Antimalarial agent 16
    		Inhibitor
    Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM).
    Antimalarial agent 16
  • HY-17530S
    Aldicarb sulfone-13C2,d3
    		Inhibitor
    Aldicarb sulfone-13C2,d3 is the deuterium and 13C labeled Aldicarb sulfone (HY-17530). Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb sulfone-<sup>13</sup>C<sub>2</sub>,d<sub>3</sub>
  • HY-115721
    Antimalarial agent 2
    		Inhibitor
    Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.
    Antimalarial agent 2
  • HY-145379
    Miaosporone A
    Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.
    Miaosporone A
  • HY-129716
    L-693989
    		Inhibitor
    L-693989 is an orally active water-soluble lipopeptide with anticandidal and antipneumocystis activity. L-693989 is effective in preventing the development of both P. carinii cysts. L-693989 is promising for research of P. carinii pneumonia.
    L-693989
  • HY-DY1024
    TPE-MI (solution)
    TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
    Solvent and concentration: DMSO: 10 mM
    TPE-MI (solution)
  • HY-157314
    HDAC6-IN-27
    		Inhibitor
    HDAC6-IN-27 (compound 8C) is a HDAC inhibitor with IC50 vales of 15.9 nM 136.5 nM and 6180.2 nM for HDAC6, HDAC8 and HDAC1, respectively. HDAC6-IN-27 shows potent antiparasitic effects.
    HDAC6-IN-27
  • HY-114489B
    Haemanthamine hydrochloride
    		Inhibitor
    Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities.
    Haemanthamine hydrochloride
  • HY-160681
    OvCHT1-IN-1
    		Inhibitor
    OvCHT1-IN-1 (compound 3i) is a potent OvCHT1 inhibitor with IC50 of 0.6 μM .
    OvCHT1-IN-1
  • HY-N12700S
    Puberulic acid-13C8
    		Inhibitor
    Puberulic acid-13C8 is the 13C-labeled Puberulic acid. Puberulic acid possesses anti-malarial activity with an IC50 value of 0.050 μM against Plasmodium falciparum K1 (chloroquine-resistant).
    Puberulic acid-<sup>13</sup>C<sub>8</sub>
  • HY-146143
    Falcipain-2/3-IN-2
    		Inhibitor
    Falcipain-2/3-IN-2 (Compound 12) is a dual falcipain-2 and falcipain-3 inhibitor.
    Falcipain-2/3-IN-2
  • HY-155846
    Antileishmanial agent-22
    		Inhibitor
    Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM.
    Antileishmanial agent-22
Parasite Isoform Comparison

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